The answer fully depends on the size of your market, population and, most importantly the amount and quality level of competition.
If you are looking to bring the joy of escaping the rooms to a completely new area - keep things simple and don't overcomplicate things. You will better use your time and effort explaining what escape room is in general, rather than explaining that AND some super-weird and creative story put on top of it. Generic themes like Prison, Heist, Murder Mystery etc are incredibly self-explanatory, which will give you chance to focus on other aspects.